3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID

Base Information

• Chemical Name: 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID
• CAS No.: 83747-30-2
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.213
• Hs Code.: 2918300090
• Mol file: 83747-30-2.mol

Synonyms:3-(1-OXO-1,3-Dihydro-2h-isoindol-2-yl)propanoic acid;3-(1-OXO-1,3-Dihydro-isoindol-2-yl)-propionic acid;

Chemical Property of 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 8.34E-09mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 447.9 °C at 760 mmHg
• Flash Point: 224.7 °C
• PSA: 57.61000
• Density: 1.325 g/cm³
• LogP: 1.05500
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(1-Oxo-1,3-dihydro-2h-isoindol-2-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID

There total 4 articles about 3-(1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-carboxybenzomethyl)-β-alanine (887643-32-5) → 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (83747-30-2)

Guidance literature:

With zinc perchlorate; In water; at 20 ℃; for 2.25h;

DOI:10.1016/j.molstruc.2013.05.017

Reference yield: 36.0%

ethyl 3-(1,3-dioxoisoindolin-2-yl)propanoate (4561-06-2) → 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (83747-30-2)

Guidance literature:

With hydrogenchloride; mercury; zinc; In water; at 100 ℃; for 5.5h;

DOI:10.1021/jm00356a023

Reference yield:

3-phthalimidopropanoic acid (3339-73-9) → 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid (83747-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: concd. H₂SO₄

2: 36 percent / Zn/Hg, concd. HCl / H₂O / 5.5 h / 100 °C

With hydrogenchloride; sulfuric acid; mercury; zinc; In water;

DOI:10.1021/jm00356a023

upstream raw materials:

ethyl 3-(1,3-dioxoisoindolin-2-yl)propanoate

3-phthalimidopropanoic acid

o-phthalic dicarboxaldehyde

3-amino propanoic acid

Downstream raw materials:

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid methyl ester

3-[1-oxo-6-(3-piperazinium-1-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]propionic acid trifluoroacetate

3-{6-[3-(4-boc-piperazin-1-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}propionic acid

3-(6-nitro-1-oxo-1,3-dihydroisoindol-2-yl)propionic acid