(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Base Information

Chemical Name:(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate
CAS No.:908350-11-8
Molecular Formula:C₂₃H₃₄N₂O₄
Molecular Weight:402.534
Hs Code.:

Synonyms:(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Suppliers and Price of (R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

There total 5 articles about (R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35373-92-3
L-phenylalanine methylamide

: 145339-42-0
(2R)-2-[1-(tert-butoxycarbonyl)vinyl]-4-methylpentanoic acid

: 908350-11-8
(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Guidance literature:: With diethylcarbamazine; benzotriazol-1-ol; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0960-894X(97)10149-4

Reference yield:

: 72594-86-6
1-benzyl 3-(tert-butyl) malonate

: 908350-11-8
(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NaH

2: 73 percent / H₂ / Pd/C / H₂O; ethanol / 5 h / 45 °C

3: 69 percent / piperidine / ethanol / 10 h / 20 °C

4: 2.9 g / hydroxybenzotriazole; EDCI / dimethylformamide / 20 °C

With piperidine; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo060058h

Reference yield:

: 184948-24-1
tert-butyl (2R)-1,2-dibenzyl 4-methylpentane-1,1,2-tricarboxylate

: 908350-11-8
(R)-tert-butyl 3-[(1S)-1-(methylcarbamoyl)-2-phenylethylcarbamoyl]-5-methyl-2-methylenehexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / H₂ / Pd/C / H₂O; ethanol / 5 h / 45 °C

2: 69 percent / piperidine / ethanol / 10 h / 20 °C

3: 2.9 g / hydroxybenzotriazole; EDCI / dimethylformamide / 20 °C

With piperidine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo060058h