1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Base Information

Chemical Name:1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline
CAS No.:353301-26-5
Molecular Formula:C₂₇H₃₂Cl₃N₂O₇PS
Molecular Weight:665.959
Hs Code.:

Synonyms:1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

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Chemical Property of 1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

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Technology Process of 1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

There total 6 articles about 1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 98-09-9
benzenesulfonyl chloride

: 353301-25-4
1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

: 353301-26-5
1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: With potassium hydride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.3987/com-01-9203

Reference yield:

: 4894-26-2
3,4-dihydro-β-carboline

: 353301-26-5
1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 82 percent / CH₂Cl₂ / 3.5 h / 20 °C

2.1: BH₃*THF / tetrahydrofuran / 1.5 h / 20 °C

2.2: 78 percent / 3M NaOH; 30 percent H₂O₂ / H₂O; tetrahydrofuran / 0.5 h / 20 °C

3.1: 81 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

4.1: 95 percent / NaI / acetone / 24 h / 20 °C

5.1: 74 percent / xylene / 4.5 h / 160 °C

6.1: 97 percent / KH / tetrahydrofuran / 1 h / 0 °C

With pyridine; borane-THF; potassium hydride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone; xylene;
DOI:10.3987/com-01-9203

Reference yield:

: 353301-21-0
1-allyl-1,2,3,4-tetrahydro-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

: 353301-26-5
1-[3-(diethoxyphosphoryl)propyl]-1,2,3,4-tetrahydro-9-phenylsulfonyl-2-(2,2,2-trichloroethoxycarbonyl)-β-carboline

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*THF / tetrahydrofuran / 1.5 h / 20 °C

1.2: 78 percent / 3M NaOH; 30 percent H₂O₂ / H₂O; tetrahydrofuran / 0.5 h / 20 °C

2.1: 81 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

3.1: 95 percent / NaI / acetone / 24 h / 20 °C

4.1: 74 percent / xylene / 4.5 h / 160 °C

5.1: 97 percent / KH / tetrahydrofuran / 1 h / 0 °C

With pyridine; borane-THF; potassium hydride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone; xylene;
DOI:10.3987/com-01-9203