4(1H)-Pyrimidinone, 2,6-diamino-5-methyl- (9CI)

Base Information

• Chemical Name: 4(1H)-Pyrimidinone, 2,6-diamino-5-methyl- (9CI)
• CAS No.: 13265-40-2
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.145
• Mol file: 13265-40-2.mol

Synonyms:4(1H)-Pyrimidinone,2,6-diamino-5-methyl- (9CI); 4-Pyrimidinol, 2,6-diamino-5-methyl- (7CI,8CI);5-Methyl-6-aminoisocytosine

Chemical Property of 4(1H)-Pyrimidinone, 2,6-diamino-5-methyl- (9CI)

Chemical Property:

• Melting Point: 275-277 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 287.4±43.0 °C(Predicted)
• PKA: 10.77±0.50(Predicted)
• PSA: 98.05000
• Density: 1.67±0.1 g/cm3(Predicted)
• LogP: 0.81740

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4(1H)-Pyrimidinone, 2,6-diamino-5-methyl- (9CI)

There total 2 articles about 4(1H)-Pyrimidinone, 2,6-diamino-5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,6-diaminopyrimidin-4-ol (56-06-4) + methyl iodide (74-88-4) → 2,4-diamino-6-hydroxy-5-methylpyrimidine (13265-40-2)

Guidance literature:

With sodium methylate;

DOI:10.1021/jm030932o

Reference yield:

→ 2,4-diamino-6-hydroxy-5-methylpyrimidine (13265-40-2)

Guidance literature:

Alkyl. von 2,4-Diamino-6-hydroxypyrimidin;

DOI:10.1021/jm00300a033

Reference yield:

2,4-diamino-6-hydroxy-5-methylpyrimidine (13265-40-2) → [2-(2,4-diamino-5-methyl-6-oxo-6H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: Cs₂CO₃ / dimethylformamide / 80 °C / sonication

1.2: 27 percent / dimethylformamide / 100 °C

2.1: 59 percent / BrSiMe₃ / acetonitrile / 20 °C

With trimethylsilyl bromide; caesium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm030932o

upstream raw materials:

2,6-diaminopyrimidin-4-ol

methyl iodide