2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

Base Information

Chemical Name:2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile
CAS No.:99280-90-7
Molecular Formula:C₂₁H₂₅N₅O₃
Molecular Weight:395.461
Hs Code.:

Synonyms:2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

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Chemical Property of 2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

Chemical Property:

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Technology Process of 2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

There total 6 articles about 2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99280-86-1
α-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-4-morpholineacetonitrile

: 107-13-1,25014-41-9
acrylonitrile

: 99280-90-7
2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 23 ℃; for 2h;
DOI:10.1021/jm00152a015

Reference yield:

: 2024-83-1
veratronitrile

: 99280-90-7
2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / HCl gas / 23 °C

2: 76 percent / NH₃ / 4 h / 68 °C / 21720.2 Torr

3: MnO₂ / tetrahydrofuran / 1.5 h / Heating

4: sodium methoxide / dimethylformamide / 6 h / 23 °C

5: p-toluenesulfonic acid monohydrate / dioxane / 1.5 h / Heating

6: KOH / tetrahydrofuran; methanol / 2 h / 23 °C

With hydrogenchloride; manganese(IV) oxide; potassium hydroxide; ammonia; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a015

Reference yield:

: 53292-69-6
2-(3,4-dimethoxyphenyl)-1H-imidazole-4-methanol

: 99280-90-7
2-<2-(3,4-dimethoxyphenyl)-1-methyl-1H-imidazol-4-yl>-2-(4-morpholinyl)pentanedinitrile

Guidance literature:: Multi-step reaction with 4 steps

1: MnO₂ / tetrahydrofuran / 1.5 h / Heating

2: sodium methoxide / dimethylformamide / 6 h / 23 °C

3: p-toluenesulfonic acid monohydrate / dioxane / 1.5 h / Heating

4: KOH / tetrahydrofuran; methanol / 2 h / 23 °C

With manganese(IV) oxide; potassium hydroxide; sodium methylate; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a015