2-glycine Ethyl Ester Hydrotosylate

Base Information

• Chemical Name: 2-glycine Ethyl Ester Hydrotosylate
• CAS No.: 70875-51-3
• Molecular Formula: C₇H₈O₃S*C₁₇H₁₉NO₃
• Molecular Weight: 457.547

Synonyms:2-glycine Ethyl Ester Hydrotosylate

Chemical Property of 2-glycine Ethyl Ester Hydrotosylate

Chemical Property:

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Technology Process of 2-glycine Ethyl Ester Hydrotosylate

There total 2 articles about 2-glycine Ethyl Ester Hydrotosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-hydroxyphenylglycine (6324-01-2) → 2-glycine Ethyl Ester Hydrotosylate (70875-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / conc.H₂SO₄ / 2 h / Heating

2: 1.) benzaldehyde, p-toluenesulfonyl acid, 2.) K₂CO₃ / 1.) DMF, 40 deg C, 12h, 2.) 60 deg C, 16h, 3.) EtOAc

With sulfuric acid; potassium carbonate; benzaldehyde; toluene-4-sulfonic acid;

DOI:10.1021/jo00328a002

Reference yield:

2-(p-Hydroxyphenyl)glycine Ethyl Ester (43189-09-9,43189-39-5) + benzyl chloride (100-44-7) + toluene-4-sulfonic acid (104-15-4) → 2-glycine Ethyl Ester Hydrotosylate (70875-51-3)

Guidance literature:

With potassium carbonate; benzaldehyde; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1.) DMF, 40 deg C, 12h, 2.) 60 deg C, 16h, 3.) EtOAc;

DOI:10.1021/jo00328a002

Reference yield: 87.0%

2-glycine Ethyl Ester Hydrotosylate (70875-51-3) + 3-Bromopropionyl chloride (15486-96-1) → 2--N-(3-bromopropionyl)glycine Ethyl Ester (70875-42-2)

Guidance literature:

With N,N-dimethyl-aniline; In dichloromethane; 1.) -20 deg C, 20 min, 2.) room temp., 1.5h;

DOI:10.1021/jo00328a002

upstream raw materials:

2-(p-Hydroxyphenyl)glycine Ethyl Ester

benzyl chloride

toluene-4-sulfonic acid

p-hydroxyphenylglycine

Downstream raw materials:

Ethyl α--2-(carbo-tert-butoxy)-1-azetidineacetate

2--N-(3-bromopropionyl)glycine Ethyl Ester

Diethyl 3-Azido-α--2-oxo-1-azetidinemalonate

Ethyl α--2-oxo-1-azetidineacetate

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