alpha-(Trifluoromethyl)cyclohexaneacetaldehyde

Base Information

Chemical Name:alpha-(Trifluoromethyl)cyclohexaneacetaldehyde
CAS No.:78659-21-9
Molecular Formula:C₉H₁₃F₃O
Molecular Weight:194.197
Hs Code.:
DSSTox Substance ID:DTXSID901264674

Synonyms:alpha-(Trifluoromethyl)cyclohexaneacetaldehyde;DTXSID901264674;78659-21-9

Suppliers and Price of alpha-(Trifluoromethyl)cyclohexaneacetaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alpha-(Trifluoromethyl)cyclohexaneacetaldehyde

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:194.09184952
Heavy Atom Count:13
Complexity:170

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(CC1)C(C=O)C(F)(F)F

Technology Process of alpha-(Trifluoromethyl)cyclohexaneacetaldehyde

There total 5 articles about alpha-(Trifluoromethyl)cyclohexaneacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 371-67-5
2,2,2-trifluorodiazoethane

: 2043-61-0
cyclohexanecarbaldehyde

: 78659-21-9
3,3,3-trifluoro-2-cyclohexyl propanal

: 78659-22-0
1-cyclohexyl-3,3,3-trifluoropropan-1-one

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 0 ℃; for 1h; Yields of byproduct given;
DOI:10.1016/S0022-1139(00)81290-7

Reference yield:

: 108-85-0
1-bromocyclohexane

: 78659-21-9
3,3,3-trifluoro-2-cyclohexyl propanal

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Mg / 1) Et₂O 2) THF, 0 deg C

2: NaH / dimethylsulfoxide

With sodium hydride; magnesium; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)74355-3

Reference yield:

: 6302-04-1
1-cyclohexyl-2,2,2-trifluoroethanone

: 78659-21-9
3,3,3-trifluoro-2-cyclohexyl propanal

Guidance literature:: Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / 1) 0 deg C 2) r.t.

2: aq. H₂SO₄ / Ambient temperature

With sulfuric acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)74355-3