(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

Base Information

Chemical Name:(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine
CAS No.:950773-01-0
Molecular Formula:C₂₀H₃₂FN₃O
Molecular Weight:349.492
Hs Code.:

Synonyms:(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

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Chemical Property of (2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

Chemical Property:

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Technology Process of (2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

There total 10 articles about (2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 950773-00-9
1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

: 950773-01-0
(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

Guidance literature:: With hydrazine; nickel; In ethanol; at 20 ℃; for 2h;

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 950773-01-0
(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

Guidance literature:: Multi-step reaction with 6 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

4: hydrogenchloride / methanol; diethyl ether / 0.17 h

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 110 °C / Microwave reactor

6: hydrazine / nickel / ethanol / 2 h / 20 °C

With hydrogenchloride; ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; nickel; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: trans-4-(ethyloxy)-1-methylcyclohexanecarboxylic acid

: 950773-01-0
(2-amino-5-fluorophenyl){1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

Guidance literature:: Multi-step reaction with 7 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 20 - 85 °C

2: hydrogenchloride / tetrahydrofuran; water / 20 °C

3: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

4: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

5: hydrogenchloride / methanol; diethyl ether / 0.17 h

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 110 °C / Microwave reactor

7: hydrazine / nickel / ethanol / 2 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; ammonia; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;