1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Base Information

Chemical Name:1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine
CAS No.:950773-00-9
Molecular Formula:C₂₀H₃₀FN₃O₃
Molecular Weight:379.475
Hs Code.:

Synonyms:1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Suppliers and Price of 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

There total 9 articles about 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-4-piperidinamine dihydrochloride

: 446-35-5
2,4-Difluoronitrobenzene

: 950773-00-9
1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110 ℃; for 0.666667h; Microwave reactor;

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 950773-00-9
1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

4: hydrogenchloride / methanol; diethyl ether / 0.17 h

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 110 °C / Microwave reactor

With hydrogenchloride; ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 950772-11-9
cis/trans-4-(ethyloxy)-1-methylcyclohexanecarboxylic acid

: 950773-00-9
1-[trans-4-(ethyloxy)-1-methylcyclohexyl]-N-(5-fluoro-2-nitrophenyl)-4-piperidinamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / toluene / 4 h / 20 - 85 °C

1.2: 0.33 h / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 20 - 85 °C

3.1: hydrogenchloride / tetrahydrofuran; water / 20 °C

4.1: potassium carbonate / ethanol; water / 2 h / 20 - 80 °C

5.1: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

6.1: hydrogenchloride / methanol; diethyl ether / 0.17 h

7.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 110 °C / Microwave reactor

With hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; ammonia; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;