2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

Base Information

Chemical Name:2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione
CAS No.:1642559-12-3
Molecular Formula:C₂₅H₂₂O₇
Molecular Weight:434.445
Hs Code.:

Synonyms:2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

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Chemical Property of 2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

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Technology Process of 2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

There total 3 articles about 2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1140509-00-7
1-ethynyl-2,3,4-trimethoxybenzene

: 32898-70-7,58845-66-2
oreoselone

: 1642559-12-3
2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

Guidance literature:: oreoselone; With trans-bis(triphenylphosphine)palladium dichloride; p-toluenesulfonyl chloride; In tetrahydrofuran; at 60 ℃; for 6h; Inert atmosphere;

1-ethynyl-2,3,4-trimethoxybenzene; With triethylamine; In tetrahydrofuran; Inert atmosphere; Reflux;
DOI:10.3390/molecules19067881

Reference yield:

: 1422972-03-9
2-isopropyl-2-(phenylethynyl)-2H-furo[3,2-g]chromene-3,7-dione

: 1642559-12-3
2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 8 h / 60 °C

2.1: gold(III) chloride / acetonitrile / 4 h / 30 °C

3.1: p-toluenesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

3.2: 6 h / 60 °C / Inert atmosphere

With gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; hydroxylamine hydrochloride; p-toluenesulfonyl chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.2174/1573406413666170601114527

Reference yield:

: (Z)-3-(hydroxyimino)-2-isopropyl-2-(phenylethynyl)-2H-furo[3,2-g]chromen-7(3H)-one

: 1642559-12-3
2-isopropyl-2-[(2,3,4-trimethoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: gold(III) chloride / acetonitrile / 4 h / 30 °C

2.1: p-toluenesulfonyl chloride; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere

2.2: 6 h / 60 °C / Inert atmosphere

With gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; p-toluenesulfonyl chloride; In tetrahydrofuran; acetonitrile;
DOI:10.2174/1573406413666170601114527