7H-Furo(3,2-G)(1)benzopyran-3,7(2H)-dione, 2-isopropyl-

Base Information

• Chemical Name: 7H-Furo(3,2-G)(1)benzopyran-3,7(2H)-dione, 2-isopropyl-
• CAS No.: 32898-70-7
• Deprecated CAS: 58845-66-2
• Molecular Formula: C₁₄H₁₂O₄
• Molecular Weight: 244.247
• UNII: T3P54V6353
• Wikidata: Q27289624
• Mol file: 32898-70-7.mol

Synonyms:AKOS000276998;Q27289624;7H-FURO(3,2-G)(1)BENZOPYRAN-3,7(2H)-DIONE, 2-ISOPROPYL-;5-BENZOFURANACRYLIC ACID, 2,3-DIHYDRO-6-HYDROXY-2-ISOPROPYL-3-OXO-, .DELTA.-LACTONE

Chemical Property of 7H-Furo(3,2-G)(1)benzopyran-3,7(2H)-dione, 2-isopropyl-

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 244.07355886
• Heavy Atom Count: 18
• Complexity: 376

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C1=C(C2=C(O1)C=C3C(=C2)C=CC(=O)O3)O

Technology Process of 7H-Furo(3,2-G)(1)benzopyran-3,7(2H)-dione, 2-isopropyl-

There total 1 articles about 7H-Furo(3,2-G)(1)benzopyran-3,7(2H)-dione, 2-isopropyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-3-(hydroxyimino)-2-isopropyl-2-(phenylethynyl)-2H-furo[3,2-g]chromen-7(3H)-one + 3-(hydroxyimino)-2-isopropyl-2-(phenylethynyl)-2H-furo[3,2-g]chromen-7(3H)-one → oreoselone (32898-70-7,58845-66-2) + 4a-isopropyl-3-phenylchromeno[6',7':4,5]furo[3,2-c][1,2]oxazin-8(4aH)-one

Guidance literature:

With gold(III) chloride; In acetonitrile; at 30 ℃; for 4h;

DOI:10.2174/1573406413666170601114527

Reference yield: 87.0%

oreoselone (32898-70-7,58845-66-2) + p-toluenesulfonyl chloride (98-59-9) → 2-(4-methylphenylsulfonyl)-2-isopropyl-2-(pyridin-2-ylethynyl)-2H-furo-[3,2-g]chromene-3,7-dione (1422972-02-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 - 60 ℃; for 4h;

DOI:10.1134/S107042801301017X

Reference yield: 80.0%

oreoselone (32898-70-7,58845-66-2) + 2-Methylphenylboronic acid (16419-60-6) → 2-isopropyl-2-(2-methylphenyl)-2H-furo[3,2-g]chromene-3,7-dione (1422972-08-4)

Guidance literature:

oreoselone; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; p-toluenesulfonyl chloride; In acetonitrile; at 80 ℃;

2-Methylphenylboronic acid; With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 80 ℃;

DOI:10.1134/S107042801301017X

Downstream raw materials:

2-(1-methylethylidene)-7H-furo[3,2-g][1]benzopyran-3,7-dione

2-isopropyl-2-(phenylethynyl)-2H-furo[3,2-g]chromene-3,7-dione

2-isopropyl-2-[(4-methoxyphenyl)ethynyl]-2H-furo[3,2-g]chromene-3,7-dione

2-(4-methylphenylsulfonyl)-2-isopropyl-2-(pyridin-2-ylethynyl)-2H-furo-[3,2-g]chromene-3,7-dione