3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester

Base Information

• Chemical Name: 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester
• CAS No.: 1027244-19-4
• Molecular Formula: C₃₅H₃₃FO₇
• Molecular Weight: 584.641
• Mol file: 1027244-19-4.mol

Synonyms:3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester

Chemical Property of 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester

There total 11 articles about 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxyxanthen-9-one (3722-51-8) → 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester (1027244-19-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / pivalic acid / toluene / 16 h / Heating

2: 99 percent / aq. HCl / tetrahydrofuran / 1 h / Ambient temperature

3: 61 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

4: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With hydrogenchloride; hydrogen; potassium carbonate; dimethyl sulfoxide; potassium iodide; Trimethylacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene; butanone;

DOI:10.1021/jm00022a006

Reference yield:

ethyl 3-<4-<9-oxo-3-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-9H-xanthene>>propanoate (152609-86-4) → 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester (1027244-19-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1021/jm00076a030

Reference yield:

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) → 3-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-9-oxo-9H-xanthen-4-yl}-propionic acid ethyl ester (1027244-19-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 61 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrachloromethane; ethanol; dimethyl sulfoxide; ethyl acetate; butanone; benzene;

DOI:10.1021/jm00022a006

upstream raw materials:

ethyl 3-<4-<9-oxo-3-<3-<5-(benzyloxy)-2-ethyl-4-(4-fluorophenyl)phenoxy>propoxy>-9H-xanthene>>propanoate

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

3-hydroxyxanthen-9-one

triethyl orthoacrylate