(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

Base Information

Chemical Name:(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide
CAS No.:1440434-18-3
Molecular Formula:C₁₈H₁₈N₂O₅
Molecular Weight:342.351
Hs Code.:

Synonyms:(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

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Chemical Property of (E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

Chemical Property:

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Technology Process of (E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

There total 4 articles about (E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130024-70-3
4-amino-2-propionylaminophenol

: 77201-71-9
(E)-3-(3,4-dihydroxyphenyl)acryloyl chloride

: 1440434-18-3
(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 331-39-5,501-16-6
caffeic acid

: 1440434-18-3
(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / Cooling with ice

2: sodium hydrogencarbonate / tetrahydrofuran; water / 4 h / 20 °C

With oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2013.04.033

Reference yield:

: 99-57-0
2-hydroxy-5-nitroaniline

: 1440434-18-3
(E)-3-(3,4-dihydroxyphenyl)-N-(4-hydroxy-3-propionamidophenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / Cooling with ice

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 4 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2013.04.033