4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

Base Information

Chemical Name:4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid
CAS No.:950661-92-4
Molecular Formula:C₂₁H₂₇N₃O₃Si
Molecular Weight:397.549
Hs Code.:

Synonyms:4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

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Chemical Property of 4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

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Technology Process of 4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

There total 5 articles about 4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 950661-91-3
5-bromo-4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine

: 124-38-9,18923-20-1
carbon dioxide

: 950661-92-4
4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: 5-bromo-4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0333333h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1016/j.bmc.2012.08.050

Reference yield: 43.0%

: 950661-92-4
4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:

Reference yield:

: 3680-71-5
Allopurinol

: 950661-92-4
4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling with ice

5.1: n-butyllithium / hexane; tetrahydrofuran / 0.03 h / -78 °C

5.2: -78 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; sodium hydride; sodium hydrogencarbonate; trichlorophosphate; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.08.050