(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

Base Information

Chemical Name:(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone
CAS No.:1435267-40-5
Molecular Formula:C₁₉H₂₀O₆
Molecular Weight:344.364
Hs Code.:

Synonyms:(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

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Chemical Property of (2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

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Technology Process of (2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

There total 9 articles about (2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2,4-bis(benzyloxy)phenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

: 1241391-92-3
3,4-dihydro-12-hydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one

: 1435267-34-7
C₁₈H₁₆O₅

: 1435267-40-5
(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

Guidance literature:: (2,4-bis(benzyloxy)phenyl)(8-((tert-butyldimethylsilyl)oxy)-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone; With triethylsilane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 0.25h; Inert atmosphere;

With caesium carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmc.2013.03.079

Reference yield:

: 1435265-49-8
tert-butyl((7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-8-yl)oxy)dimethylsilane

: 1241391-92-3
3,4-dihydro-12-hydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one

: 1435267-34-7
C₁₈H₁₆O₅

: 1435267-40-5
(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 0.25 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 24 h

4.1: palladium 10% on activated carbon; triethylsilane / methanol; tetrahydrofuran / 0.25 h / Inert atmosphere

4.2: 0.25 h / 140 °C / Microwave irradiation

With triethylsilane; N-Bromosuccinimide; n-butyllithium; palladium 10% on activated carbon; ammonium acetate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmc.2013.03.079

Reference yield:

: 1435265-53-4
C₁₈H₂₉BrO₃Si

: 1241391-92-3
3,4-dihydro-12-hydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one

: 1435267-34-7
C₁₈H₁₆O₅

: 1435267-40-5
(2,4-dihydroxyphenyl)(8-hydroxy-7-methoxy-2,2-dimethyl-3,4-dihydrobenzopyran-6-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 24 h

3.1: palladium 10% on activated carbon; triethylsilane / methanol; tetrahydrofuran / 0.25 h / Inert atmosphere

3.2: 0.25 h / 140 °C / Microwave irradiation

With triethylsilane; n-butyllithium; palladium 10% on activated carbon; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.03.079