N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Base Information

Chemical Name:N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
CAS No.:1350473-40-3
Molecular Formula:C₃₀H₄₃N₅O₂Si
Molecular Weight:533.789
Hs Code.:

Synonyms:N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

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Chemical Property of N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

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Technology Process of N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

There total 11 articles about N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1185428-39-0
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 1350473-39-0
1-benzyl-4,4-dimethylpiperidin-3-amine

: 1350473-40-3
N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1334674-88-2
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-40-3
N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / water; acetone

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

4.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium chloride; tricyclohexylphosphine; palladium diacetate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-40-3
N-(1-benzyl-4,4-dimethylpiperidin-3-yl)-2-cyclopropyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

1.2: pH 4

2.1: Jones reagent / water; acetone

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

5.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium chloride; sodium hydroxide; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil;