racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Base Information

• Chemical Name: racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole
• CAS No.: 1059630-12-4
• Molecular Formula: C₁₁H₁₃BrN₂
• Molecular Weight: 253.142

Synonyms:racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Chemical Property of racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

Chemical Property:

• Boiling Point: 338.4±42.0 °C(Predicted)
• Density: 1.416±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

There total 3 articles about racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloric acid salt (1059630-11-3) → racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (1059630-12-4)

Guidance literature:

6-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloric acid salt; With triethylsilane; trifluoroacetic acid; at 20 ℃; for 19h;

With sodium hydroxide; In water; pH=10;

Reference yield:

2-bromophenylhydrazine hydrochloride (50709-33-6) → racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (1059630-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / Reflux

2: triethylsilane; trifluoroacetic acid

With hydrogenchloride; triethylsilane; trifluoroacetic acid; In ethanol;

DOI:10.1358/dof.2015.040.10.2387229

Reference yield:

piperidine-4,4-diol hydrochloride (40064-34-4) → racemate 6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (1059630-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / Reflux

2: triethylsilane; trifluoroacetic acid

With hydrogenchloride; triethylsilane; trifluoroacetic acid; In ethanol;

DOI:10.1358/dof.2015.040.10.2387229

upstream raw materials:

6-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloric acid salt

2-bromophenylhydrazine hydrochloride

piperidine-4,4-diol hydrochloride

Downstream raw materials:

(4aS,9bR)-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole (S)-(+)-mandelic acid salt

[4aS,9bR]-6-bromo-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole

(4aS,9bR)-ethyl 6-bromo-3,4,4a,5-tetrahydro-1H-pyrido[4,3-b]indole-2(9bH)-carboxylate

(6bR,10aS)-ethyl 2,3,6b,9,10,10a-hexahydro-3-methyl-2-oxo-1H-pyrido[3‘,4’:4,5]-pyrrolo[1,2,3-de]quinoxaline-8-carboxylate

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