2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

Base Information

Chemical Name:2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one
CAS No.:816447-27-5
Molecular Formula:C₃₁H₂₆O₃
Molecular Weight:446.546
Hs Code.:

Synonyms:2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

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Chemical Property of 2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

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Technology Process of 2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

There total 9 articles about 2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 190661-29-1
2-benzyloxyphenylboronic acid

: 816447-26-4
2-bromo-3-(4-methoxyphenyl)-4-phenyl-cyclopent-2-en-1-one

: 816447-27-5
2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; at 120 ℃; Temperature; Inert atmosphere; Microwave irradiation;
DOI:10.1021/acs.joc.1c01039

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 816447-27-5
2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C

2.1: nBuLi / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 63 percent / trimethyl borate / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

3.1: 46 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / toluene; H₂O / 48 h / 110 °C

With n-butyllithium; sodium carbonate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene; 3.1: Suzuki coupling;
DOI:10.1021/ol0479904

Reference yield:

: 31575-75-4
2-bromophenyl benzyl ether

: 816447-27-5
2-[2-(benzyloxy)phenyl]-3-(4-methoxyphenyl)-4-phenylcyclopent-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 63 percent / trimethyl borate / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C

2.1: 46 percent / Na₂CO₃ / PdCl₂(PPh₃)2 / toluene; H₂O / 48 h / 110 °C

With n-butyllithium; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; water; toluene; 2.1: Suzuki coupling;
DOI:10.1021/ol0479904