methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

Base Information

Chemical Name:methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate
CAS No.:446284-68-0
Molecular Formula:C₁₁H₉ClN₂O₄
Molecular Weight:268.656
Hs Code.:

Synonyms:methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

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Chemical Property of methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

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Technology Process of methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

There total 1 articles about methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 446284-68-0
methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2: copper(l) iodide / methanol / 110 °C / Microwave irradiation; Inert atmosphere

3: aluminum (III) chloride / dichloromethane / 2 h / 20 °C

With aluminum (III) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.10.027

Reference yield:

: 446284-68-0
methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

: C₁₃H₁₆N₂O*ClH

: C₂₃H₂₁ClN₄O₄

Guidance literature:: methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate; With potassium carbonate; In methanol; water; at 20 ℃; for 8h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; N,N-dimethyl-formamide; for 1h;

C₁₃H₁₆N₂O*ClH; In methanol; water; N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2014.10.027

Reference yield:

: 446284-68-0
methyl 2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate

: 446285-02-5
1-(4-benzoylpiperazin-1-yl)-2-(7-chloro-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium hydroxide; water / tetrahydrofuran; methanol

2: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

With water; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;