BMS 663068 (Tris)

Base Information

• Chemical Name: BMS 663068 (Tris)
• CAS No.: 864953-39-9
• Molecular Formula: C₄H₁₁NO₃*C₂₅H₂₆N₇O₈P
• Molecular Weight: 704.634
• Mol file: 864953-39-9.mol

Synonyms:Fostemsavir Tris;BMS663068 (Tris);BMS 663068 (Tris);BMS-663068 (Tris);Fostemsavir tromethamine;Fostemsavir Tris (BMS-663068 Tris);BMS663068 (TRIS); BMS 663068 (TRIS);Fostemsavir Tris (BMS-663068 trisaminomethane)

Chemical Property of BMS 663068 (Tris)

Chemical Property:

• PSA: 278.73000
• LogP: -0.59500

Purity/Quality:

99% ^*data from raw suppliers

FostemsavirTris(BMS-663068Tris) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BMS 663068 (Tris)

There total 39 articles about BMS 663068 (Tris) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C27H30N7O8P + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl hydrogen phosphate (864953-39-9)

Guidance literature:

With acetic acid; In 1,4-dioxane; water;

Reference yield: 82.0%

(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl di-tert-butyl phosphate + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl hydrogen phosphate (864953-39-9)

Guidance literature:

(3-(2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl)-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)methyl di-tert-butyl phosphate; With water; In acetone; at 40 ℃; Inert atmosphere;

2-amino-2-hydroxymethyl-1,3-propanediol; In acetone; at 40 ℃; for 1h;

DOI:10.1021/acs.jmedchem.8b00759

Reference yield: 51.0%

fostemsavir (864953-29-7) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine di-tris salt (864953-39-9)

Guidance literature:

In water; pH=1.02 - 7.32;

upstream raw materials:

fostemsavir

2-amino-2-hydroxymethyl-1,3-propanediol

N-(5-bromo-4-methylpyridin-2-yl)acetamide

2-amino-3-nitro-4-methyl-5-bromopyridine