6-methoxynaphthalen-2-amine

Base Information

• Chemical Name: 6-methoxynaphthalen-2-amine
• CAS No.: 13101-88-7
• Molecular Formula: C11H11 N O
• Molecular Weight: 173.214
• Hs Code.: 2922299090
• Mol file: 13101-88-7.mol

Synonyms:2-Naphthylamine,6-methoxy- (6CI,7CI,8CI); 2-Amino-6-methoxynaphthalene;6-Methoxy-2-naphthalenamine; 6-Methoxy-2-naphthylamine

Chemical Property of 6-methoxynaphthalen-2-amine

Chemical Property:

• Melting Point: 139-140 °C
• Boiling Point: 347.4±15.0 °C(Predicted)
• PKA: 4.47±0.10(Predicted)
• PSA: 35.25000
• Density: 1.156±0.06 g/cm3(Predicted)
• LogP: 3.01180
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxynaphthalen-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-methoxynaphthalen-2-amine

There total 26 articles about 6-methoxynaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

tert-butyl N-(6-methoxynaphthalen-2-yl)carbamate (479630-55-2) → 6-methoxy-2-naphthylamine (13101-88-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1124/mol.113.087502

Reference yield: 95.0%

6-methoxy-2-acetylnaphthalene (3900-45-6) → 6-methoxy-2-naphthylamine (13101-88-7)

Guidance literature:

With methanol; O-benzenesulfonyl-acetohydroxamic acid ethyl ester; toluene-4-sulfonic acid; at 23 ℃; for 9h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00807

Reference yield: 93.0%

6-methoxy-2-propionylnaphthalene (2700-47-2) → 6-methoxy-2-naphthylamine (13101-88-7)

Guidance literature:

With methanol; ethyl O-(methanesulfonyl)acetohydroxamate; toluene-4-sulfonic acid; at 23 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00807

upstream raw materials:

6-Methoxy-2-naphthol

2-Bromo-6-methoxynaphthalene

6-methoxy-2-naphthamide

6-nitro-2-methoxynaphthalene

Refernces

• 1、 Arae, Sachie,Mori, Takaaki,Kawatsu, Takahiro,Ueda, Daiki,Shigeta, Yusuke,Hamamoto, Nobutsugu,Fujimoto, Hitoshi,Sumimoto, Michinori,Imahori, Tatsushi,Igawa, Kazunobu,Tomooka, Katsuhiko,Punniyamurthy, Tharmalingam,Irie, Ryo. "Synthesis and stereochemical properties of chiral hetero[7]helicenes structured by a benzodiheterole ring core". . p. 1214 - 1216. Retrieved 2017.
• 2、 Ji, Jieying,Jiang, Quanbin,Liang, Yaoyu,Luo, Jie,Zhang, Xiaoyan,Zhao, Xiaodan. "Enantioselective Construction of Axially Chiral Amino Sulfide Vinyl Arenes by Chiral Sulfide-Catalyzed Electrophilic Carbothiolation of Alkynes". supporting information. p. 4959 - 4964. Retrieved 2020/02/11.
• 3、 -. "PRODUCTION METHOD OF PRIMARY AMINE COMPOUND". Paragraph 0026; 0027; 0029. . Retrieved 2019/09/20.