6-Methoxy-2-naphthol

Base Information

• Chemical Name: 6-Methoxy-2-naphthol
• CAS No.: 5111-66-0
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Hs Code.: 2909500000
• Mol file: 5111-66-0.mol

Synonyms:2-Naphthol,6-methoxy- (6CI,7CI,8CI);2-Hydroxy-6-methoxynaphthalene;2-Methoxy-6-naphthol;6-Methoxy-2-hydroxynaphthalene;6-Methoxy-2-naphthalenol;6-Methoxy-2-naphthol;6-Methoxy-b-naphthol;NSC 149908;

Chemical Property of 6-Methoxy-2-naphthol

Chemical Property:

• Vapor Pressure: 5.65E-05mmHg at 25°C
• Melting Point: 148-152 °C
• Refractive Index: 1.64
• Boiling Point: 336.7 °C at 760 mmHg
• PKA: 9.76±0.40(Predicted)
• Flash Point: 211.8 °C
• PSA: 29.46000
• Density: 1.193 g/cm³
• LogP: 2.55400
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

≥99% ^*data from raw suppliers

6-Methoxy-2-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.

Technology Process of 6-Methoxy-2-naphthol

There total 2 articles about 6-Methoxy-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dibromobutane (5408-86-6) + 2-Bromo-6-methoxynaphthalene (5111-65-9) → 2-Methoxynaphthalene (93-04-9) + 6-Methoxy-2-naphthol (5111-66-0) + 3-(6-methoxy-2-naphthyl)-2-butanone (56600-77-2) + 6,6'-dimethoxy-2,2'-binaphthalene (29619-45-2) + 2,2′-(1,2-dimethyl-1,2-ethanediyl)di-(6-methoxynaphthalene)

Guidance literature:

2-Bromo-6-methoxynaphthalene; With magnesium; ethylene dibromide; In tetrahydrofuran; at 35 - 40 ℃; for 12.75h;

2,3-dibromobutane; With (FeCl₃)2(TMEDA)3; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

2.6-dihydroxynaphthalene (581-43-1) + dimethyl sulfate (77-78-1) → 2,6-dimethoxylnaphthalene (5486-55-5,117119-43-4) + 6-Methoxy-2-naphthol (5111-66-0)

Guidance literature:

With soude; In water; for 6h; Heating;

DOI:10.1016/0040-4020(82)87012-9

Reference yield: 96.0%

BARBITURIC ACID (67-52-7,944357-77-1) + 1-benzylisatin (1217-89-6) + 6-Methoxy-2-naphthol (5111-66-0) → 1'-benzyl-3-methoxy-spiro[benzo[5,6]chromeno[2,3-d]pyrimidine-3',12-indoline]-2',9,11-(10H,8H)-trione

Guidance literature:

With [HMIm][HSO₄] immobilized Fe₃O₄ on MCM-41-SO₃H nanoparticles; In neat (no solvent); at 100 ℃; for 0.25h; Reagent/catalyst;

DOI:10.1016/j.molliq.2015.06.007

upstream raw materials:

2.6-dihydroxynaphthalene

dimethyl sulfate

2,3-dibromobutane

2-Bromo-6-methoxynaphthalene

Downstream raw materials:

2-hydroxy-6-methoxy-1,2,3,4-tetrahydronaphthalene

6-methoxy-2-naphthylamine

3-hydroxydibenzacridine

2,6-dimethoxylnaphthalene