(S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid

Base Information

• Chemical Name: (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid
• CAS No.: 157683-99-3
• Molecular Formula: C₁₅H₂₀ClNO₄
• Molecular Weight: 313.781
• Mol file: 157683-99-3.mol

Synonyms:(S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid

Chemical Property of (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid

There total 3 articles about (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

di-tert-butyl dicarbonate (24424-99-5) + C14H17ClN2O4 → (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid (157683-99-3)

Guidance literature:

C₁₄H₁₇ClN₂O₄; With potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 5h;

DOI:10.1002/anie.201306583

Reference yield:

(S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid methyl ester (1257614-37-1) → (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid (157683-99-3)

Guidance literature:

(S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid methyl ester; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; pH=~ 1;

Reference yield:

1-Chloro-4-iodobenzene (637-87-6) → (S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid (157683-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium diacetate; silver(I) acetate; Trimethylacetic acid / 24 h / 100 °C / Sealed tube; Darkness

2.1: potassium hydroxide / 1,4-dioxane; water / 12 h / 20 °C

2.2: 5 h / 0 - 20 °C

With silver(I) acetate; palladium diacetate; potassium hydroxide; Trimethylacetic acid; In 1,4-dioxane; water;

DOI:10.1002/anie.201306583

upstream raw materials:

(S)-2-tert-butoxycarbonylamino-4-(4-chloro-phenyl)-butyric acid methyl ester

di-tert-butyl dicarbonate

1-Chloro-4-iodobenzene