(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Base Information

Chemical Name:(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester
CAS No.:1053614-60-0
Molecular Formula:C₂₁H₃₄N₄O₄
Molecular Weight:406.525
Hs Code.:

Synonyms:(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Suppliers and Price of (3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

There total 5 articles about (3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 1053614-60-0
(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Li₂CuCl₄ / 1.) THF, ether, -35 deg C, 40 min, 2.) THF, ether, ether, 3 h

2: K₂CO₃ / methanol / 1 h / Ambient temperature

3: 1.) CuI / 1.) THF, ether, -40 deg C, 10 min, 2.) THF, ether, -40 deg C, 1 h

4: BF₃*Et₂O / 2 h / 70 - 75 °C

5: pyridine, (dimethylamino)pyridine / 18 h / Ambient temperature

With pyridine; dmap; copper(l) iodide; dilithium tetrachlorocuprate; boron trifluoride diethyl etherate; potassium carbonate; In methanol;
DOI:10.1021/jm980162u

Reference yield:

: Toluene-4-sulfonic acid (R)-3-cyclohexyl-2-hydroxy-propyl ester

: 1053614-60-0
(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / methanol / 1 h / Ambient temperature

2: 1.) CuI / 1.) THF, ether, -40 deg C, 10 min, 2.) THF, ether, -40 deg C, 1 h

3: BF₃*Et₂O / 2 h / 70 - 75 °C

4: pyridine, (dimethylamino)pyridine / 18 h / Ambient temperature

With pyridine; dmap; copper(l) iodide; boron trifluoride diethyl etherate; potassium carbonate; In methanol;
DOI:10.1021/jm980162u

Reference yield:

: 149182-14-9
(S)-1-cyclohexyl-2-butanol

: 1053614-60-0
(3R,4R,5S)-4-Acetylamino-5-azido-3-((S)-1-cyclohexylmethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*Et₂O / 2 h / 70 - 75 °C

2: pyridine, (dimethylamino)pyridine / 18 h / Ambient temperature

With pyridine; dmap; boron trifluoride diethyl etherate;
DOI:10.1021/jm980162u