N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

Base Information

Chemical Name:N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide
CAS No.:1298120-44-1
Molecular Formula:C₂₃H₂₄N₂O₇
Molecular Weight:440.453
Hs Code.:

Synonyms:N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

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Chemical Property of N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

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Technology Process of N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

There total 4 articles about N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 158211-98-4
(2R,3S)-3-amino-2-hydroxy-4-phenylbutanamide

: 1298119-91-1
6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxylic acid

: 1298120-44-1
N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.02.025

Reference yield:

: 1298119-85-3
ethyl 6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxylate

: 1298120-44-1
N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

1.2: pH 2

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.025

Reference yield:

: 2033-89-8
3,4-dimethoxyphenol

: 1298120-44-1
N-((2S,3R)-4-amino-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-6,7-dimethoxy-3-methyl-4-oxo-4H-chromene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / 80 - 85 °C

2.1: pyridine / 12 h / Reflux

3.1: potassium hydroxide / ethanol; water / 1 h / 20 °C

3.2: pH 2

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With pyridine; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; 1.1: Fries rearrangement;
DOI:10.1016/j.ejmech.2011.02.025