2,4,6-TRIMETHOXYCINNAMIC ACID

Base Information

• Chemical Name: 2,4,6-TRIMETHOXYCINNAMIC ACID
• CAS No.: 13063-09-7
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 13063-09-7.mol

Synonyms:Cinnamicacid, 2,4,6-trimethoxy- (7CI,8CI)

Chemical Property of 2,4,6-TRIMETHOXYCINNAMIC ACID

Chemical Property:

• Melting Point: 217-218 °C
• Boiling Point: 428.2±40.0 °C(Predicted)
• PKA: 4.61±0.21(Predicted)
• PSA: 64.99000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 1.81020

Purity/Quality:

98%min ^*data from raw suppliers

2,4,6-TrimethoxycinnamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,6-TRIMETHOXYCINNAMIC ACID

There total 4 articles about 2,4,6-TRIMETHOXYCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → 2,4,6-trimethoxy-cinnamic acid (13063-09-7)

Guidance literature:

With pyridine;

DOI:10.1001/jama.287.14.1802

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → 2,4,6-trimethoxy-cinnamic acid (13063-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnCl₂; benzene; HCl / Reaktion des entstandenen Aldimids mit waessr. Salzsaeure

2: pyridine

With pyridine; hydrogenchloride; zinc(II) chloride; benzene;

DOI:10.1001/jama.287.14.1802

Reference yield:

pyridine (110-86-1) + malonic acid (141-82-2) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → 2,4,6-trimethoxy-cinnamic acid (13063-09-7)

Guidance literature:

DOI:10.1001/jama.287.14.1802

upstream raw materials:

pyridine

malonic acid

2,4,6-trimethoxybenzaldehyde

1,2,3-trimethoxybenzene

Downstream raw materials:

(E)-3-(2,4,6-trimethoxy-phenyl)-acrylic acid methyl ester

Refernces

• 1、 Peng, Shiyong,Chen, Nuan,Zhang, Hong,He, Min,Li, Hongguang,Lang, Ming,Wang, Jian. "Palladium(II)-Catalyzed Oxidative Decarboxylative [2 + 2 + 1] Annulation of Cinnamic Acids with Alkynes: Access to Polysubstituted Pentafulvenes". supporting information. p. 5589 - 5593. Retrieved 2020/07/08.