6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

Base Information

Chemical Name:6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran
CAS No.:215876-20-3
Molecular Formula:C₄₆H₈₄O₇Si₃
Molecular Weight:833.425
Hs Code.:

6-{3-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2<i>H</i>-pyran

Synonyms:6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

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Chemical Property of 6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

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Technology Process of 6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

There total 35 articles about 6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 247146-64-1
C₅₄H₉₂O₁₁SSi₃

: 215876-20-3
6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

Guidance literature:: With ethanol; magnesium; mercury dichloride;
DOI:10.1021/ja990860j

Reference yield:

: 215876-11-2
(2R,4S,6S)-2-Benzyloxymethyl-6-hydroxymethyl-tetrahydro-pyran-4-ol

: 215876-20-3
6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole; DMAP / CH₂Cl₂

2.1: H₂; AcOH / 10 percent Pd/C / ethyl acetate / 760 Torr

3.1: 85 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -50 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: tetrahydrofuran / -78 - -50 °C

5.1: DMAP / CH₂Cl₂

6.1: 64 percent / Mg; HgCl₂; EtOH

With 1H-imidazole; dmap; n-butyllithium; oxalyl dichloride; ethanol; hydrogen; magnesium; acetic acid; dimethyl sulfoxide; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 1.1: silylation / 2.1: Hydrogenolysis / 3.1: Oxidation / 4.1: Metallation / 4.2: Substitution / 5.1: Acetylation / 6.1: Deacetylation;
DOI:10.1021/ja990860j

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 215876-20-3
6-{3-[4-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-pyran-2-yl]-1,1-dimethyl-allyl}-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butyl]-3,4-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole; DMAP / CH₂Cl₂

2.1: H₂; AcOH / 10 percent Pd/C / ethyl acetate / 760 Torr

3.1: 85 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -50 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: tetrahydrofuran / -78 - -50 °C

5.1: DMAP / CH₂Cl₂

6.1: 64 percent / Mg; HgCl₂; EtOH

With 1H-imidazole; dmap; n-butyllithium; oxalyl dichloride; ethanol; hydrogen; magnesium; acetic acid; dimethyl sulfoxide; triethylamine; mercury dichloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 1.1: silylation / 2.1: Hydrogenolysis / 3.1: Oxidation / 4.1: Metallation / 4.2: Substitution / 5.1: Acetylation / 6.1: Deacetylation;
DOI:10.1021/ja990860j