C₅₄H₄₈N₂O₇

Base Information

• Chemical Name: C₅₄H₄₈N₂O₇
• CAS No.: 1426060-05-0
• Molecular Formula: C₅₄H₄₈N₂O₇
• Molecular Weight: 836.984
• Mol file: 1426060-05-0.mol

Synonyms:C₅₄H₄₈N₂O₇

Chemical Property of C₅₄H₄₈N₂O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₄H₄₈N₂O₇

There total 1 articles about C₅₄H₄₈N₂O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(S)-tyrosine benzyl ester (52799-86-7) + Fmoc-Tyr(Bzl)-OH (71989-40-7) → C54H48N2O7 (1426060-05-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1002/anie.201207456

Reference yield: 50.0%

C54H48N2O7 (1426060-05-0) → (3S,6S)-3,6-bis(p-(benzyloxy)benzyl)piperazine-2,5-dione (374674-80-3)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/anie.201207456

Reference yield:

C54H48N2O7 (1426060-05-0) → 4,4′-(((2S,5S)-piperazine-2,5-diyl)bis(methylene))diphenol

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / N,N-dimethyl-formamide / 20 °C

2: lithium aluminium tetrahydride / diethyl ether / 1 h / 60 °C

3: palladium 10% on activated carbon; hydrogen / ethanol; acetic acid / 12 h / 20 °C / Inert atmosphere

With piperidine; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In diethyl ether; ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1002/anie.201207456

upstream raw materials:

(S)-tyrosine benzyl ester

Fmoc-Tyr(Bzl)-OH

Downstream raw materials:

(3S,6S)-3,6-bis(p-(benzyloxy)benzyl)piperazine-2,5-dione

(2S,5S)-2,5-bis(4-(benzyloxy)benzyl)piperazine

Refernces