(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

Base Information

Chemical Name:(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine
CAS No.:345287-89-0
Molecular Formula:C₅₂H₈₇N₂O₈P
Molecular Weight:899.245
Hs Code.:

Synonyms:(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

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Chemical Property of (+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

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Technology Process of (+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

There total 4 articles about (+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 345287-86-7
(-)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycerol

: 345287-89-0
(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃;
DOI:10.1039/b909306k

Reference yield: 88.0%

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 345287-86-7
(-)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycerol

: 345287-89-0
(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

Guidance literature:: With 1H-tetrazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/b200585a

Reference yield:

: 345287-87-8
(+)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol

: 345287-89-0
(+)-(benzyloxy){1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2-O-hexadecanoyl-sn-glycer-3-O-yl}(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMAP; pyridine / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 70 percent / CH₂Cl₂ / 20 °C

2.1: 91 percent / dichloro(dicyano)quinone; H₂O / CH₂Cl₂ / 20 °C

3.1: 88 percent / 1H-tetrazole / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 1H-tetrazole; dmap; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1039/b200585a