4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

Base Information

Chemical Name:4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole
CAS No.:452056-94-9
Molecular Formula:C₂₀H₂₁FN₄OS
Molecular Weight:384.477
Hs Code.:

Synonyms:4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

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Chemical Property of 4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

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Technology Process of 4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

There total 3 articles about 4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 452056-89-2
N-{4-[5-(4-fluorophenyl)-3-propyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl]pyridin-2-yl}acetamide

: 74-88-4
methyl iodide

: 452056-94-9
4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

Guidance literature:: With sodium carbonate; In tetrahydrofuran; ethanol; Heating;
DOI:10.1021/jm030766k

Reference yield:

: 452056-82-5
N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide

: 452056-94-9
4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / ethanol / 10 h / Heating

2: 90 percent / 2,2,4,4-tetramethylcyclobutane-1,3-dithione / CH₂Cl₂ / 1 h / 20 °C

3: 37 percent / Na₂CO₃ / ethanol; tetrahydrofuran / Heating

With 2,2,4,4-tetramethylcyclobutane-1,3-dithione; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030766k

Reference yield:

: 452056-84-7
N-{4-[5-(4-fluorophenyl)-1-oxy-3-propyl-3H-imidazol-4-yl]pyridin-2-yl}acetamide

: 452056-94-9
4-(4-Fluorophenyl)-1-n-propyl-5-(2-acetamido-4-pyridyl)-2-methylthioimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 2,2,4,4-tetramethylcyclobutane-1,3-dithione / CH₂Cl₂ / 1 h / 20 °C

2: 37 percent / Na₂CO₃ / ethanol; tetrahydrofuran / Heating

With 2,2,4,4-tetramethylcyclobutane-1,3-dithione; sodium carbonate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030766k