(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

Base Information

Chemical Name:(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate
CAS No.:1164114-96-8
Molecular Formula:C₅₄H₉₄O₁₀SSi₃
Molecular Weight:1019.66
Hs Code.:

(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

Synonyms:(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

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Chemical Property of (2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

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Technology Process of (2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

There total 1 articles about (2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1164115-14-3
C₅₈H₉₉NO₁₂Si₃

: 75-08-1
ethanethiol

: 1164114-96-8
(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

Guidance literature:: ethanethiol; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

C₅₈H₉₉NO₁₂Si₃; In tetrahydrofuran; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ol900757k DOI:10.1002/chem.201000104

Reference yield: 94.0%

: 1164114-96-8
(2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate

: 1164115-15-4
C₅₂H₉₀O₁₀Si₃

Guidance literature:: (2R,3S,E)-S-ethyl-5-((4R,5R)-4-(2-(tert-butyldimethylsilyloxy)ethyl)-2-(2,4-dimethoxyphenyl)-5-((R)-3-(4-methoxybenzyloxy)-2-(triisopropylsilyloxy)propyl)-1,3-dioxolan-4-yl)-2-ethyl-3-(triethylsilyloxy)pent-4-enethioate; With diisobutylaluminium hydride; In toluene; pentane; at -78 ℃; Inert atmosphere;

With water; Rochelle's salt; In dichloromethane; pentane; for 1.5h;
DOI:10.1021/ol900757k