C₁₂H₁₄Cl₂O₃

Base Information

• Chemical Name: C₁₂H₁₄Cl₂O₃
• CAS No.: 1058856-50-0
• Molecular Formula: C₁₂H₁₄Cl₂O₃
• Molecular Weight: 277.147
• Mol file: 1058856-50-0.mol

Synonyms:C₁₂H₁₄Cl₂O₃

Chemical Property of C₁₂H₁₄Cl₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₄Cl₂O₃

There total 5 articles about C₁₂H₁₄Cl₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (E)-4-(2,4-dichlorophenyl)-2-oxobut-3-enoate (875018-47-6) → C12H14Cl2O3 (1058856-50-0)

Guidance literature:

With hydrogenchloride; [NH2Me2]+[{RuCl[(S)-SunPhos]}2(μ-Cl3)]; hydrogen; In ethanol; water; at 70 ℃; for 12h; under 10501.1 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/jo801140j

Reference yield:

ethanol (64-17-5) + C10H10Cl2O3 (1327337-56-3) → C12H14Cl2O3 (1058856-50-0)

Guidance literature:

With sulfuric acid; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/jo101084t

Reference yield:

C10H8Cl2O3 (1260521-21-8) → C12H14Cl2O3 (1058856-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen / tetrahydrofuran; water / 20 h / 70 °C / 20686.5 Torr / Autoclave

2: sulfuric acid / 5 h / Inert atmosphere; Reflux

With sulfuric acid; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen; In tetrahydrofuran; water;

DOI:10.1016/j.tet.2011.06.071

upstream raw materials:

ethyl (E)-4-(2,4-dichlorophenyl)-2-oxobut-3-enoate

ethanol

C₁₀H₁₀Cl₂O₃

C₁₀H₈Cl₂O₃