3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one

Base Information

• Chemical Name: 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one
• CAS No.: 1268276-47-6
• Molecular Formula: C₂₇H₁₈ClN₅O₅
• Molecular Weight: 527.923

Synonyms:3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one

Chemical Property of 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one

Chemical Property:

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Technology Process of 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one

There total 3 articles about 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one (7033-52-5) + 4,4'-methylenebis(m-nitroaniline) (26946-33-8) → 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one (1268276-47-6)

Guidance literature:

With pyridine; for 6h; Reflux;

DOI:10.1016/j.dyepig.2010.10.013

Reference yield:

3-nitro-aniline (99-09-2) → 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one (1268276-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 50 °C

1.2: 1 h / 60 °C

2.1: pyridine / 6 h / Reflux

With pyridine; hydrogenchloride; In water;

DOI:10.1016/j.dyepig.2010.10.013

Reference yield:

benzoyl chloride (98-88-4) → 3-{4-[4-amino-2-nitrobenzyl]-3-nitrophenyl}-7-chloro-2-phenylquinazolin-4(3H)-one (1268276-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 3 h / 0 - 20 °C

2: pyridine / 6 h / Reflux

With pyridine;

DOI:10.1016/j.dyepig.2010.10.013

upstream raw materials:

benzoyl chloride

3-nitro-aniline

7-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one

4,4'-methylenebis(m-nitroaniline)

Downstream raw materials:

C₄₆H₂₈Cl₃N₁₁O₅

C₄₆H₂₇Cl₃N₁₁O₉S^(1-)*Na⁽¹⁺⁾

C₄₇H₂₉Cl₃N₁₁O₉S^(1-)*Na⁽¹⁺⁾

C₅₂H₃₁Cl₃N₁₁O₉S^(1-)*Na⁽¹⁺⁾

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