(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

Base Information

Chemical Name:(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide
CAS No.:1144016-33-0
Molecular Formula:C₁₃H₁₂F₃N₃OS
Molecular Weight:315.319
Hs Code.:

Synonyms:(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

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Technology Process of (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

There total 1 articles about (2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1144016-15-8
DF₂₇₀₃Y

: 1144016-33-0
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

Guidance literature:: DF₂₇₀₃Y; With 1,1'-carbonyldiimidazole; In dichloromethane; at 0 - 5 ℃; for 1h;

With ammonia; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1144016-33-0
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

: 1144015-82-6
N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: toluene / 1.5 h / 130 °C / Microwave irradiation

3.1: hydrogenchloride / water / 1 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water; toluene;
DOI:10.1016/j.tetlet.2013.09.022