N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine
CAS No.:1144015-82-6
Molecular Formula:C₁₃H₁₁F₃N₆S
Molecular Weight:340.332
Hs Code.:

Synonyms:N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

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Chemical Property of N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

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Technology Process of N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

There total 4 articles about N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1144016-35-2
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanenitrile

: 1144015-82-6
N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

Guidance literature:: With trimethylsilylazide; tetrabutyl ammonium fluoride; at 85 ℃; for 18h;

Reference yield:

: C₁₆H₁₉F₃N₆SSn

: 1144015-82-6
N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Temperature;
DOI:10.1016/j.tetlet.2013.09.022

Reference yield:

: 1144016-33-0
(2R)-2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanamide

: 1144015-82-6
N-{4-[(1R)-1-(1H-tetrazol-5-yl)ethyl]phenyl}-4-(trifluoromethyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: toluene / 1.5 h / 130 °C / Microwave irradiation

3.1: hydrogenchloride / water / 1 h / 20 °C

With hydrogenchloride; triethylamine; In dichloromethane; water; toluene;
DOI:10.1016/j.tetlet.2013.09.022