N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide
CAS No.:228266-39-5
Molecular Formula:C₃₄H₅₅N₃O₆
Molecular Weight:601.827
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

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Chemical Property of N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

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Technology Process of N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

There total 8 articles about N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl (S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoate trifluoroacetic acid salt

: 228266-38-4
N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine

: 228266-39-5
N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

: ethyl (R)-N-tert-butoxycarbonyl-N,β,β-trimethylphenylalanyl-(S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/np020375t

Reference yield:

: ethyl (S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoate trifluoroacetic acid salt

: C₂₂H₃₃NO₅

: pivaloyl-(S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoic acid ethyl ester

: 228266-39-5
N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/np020375t

Reference yield:

: methyl N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine ester

: 228266-39-5
N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.218 mmol / aq. LiOH / methanol / 60 °C

2: 35.2 mg / diisopropylethylamine; PyBOP / CH₂Cl₂ / 20 h / 20 °C

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/np020375t