Taltobulin (trifluoroacetate)

Base Information

• Chemical Name: Taltobulin (trifluoroacetate)
• CAS No.: 228266-41-9
• Molecular Formula: C₂HF₃O₂*C₂₇H₄₃N₃O₄
• Molecular Weight: 587.68
• Mol file: 228266-41-9.mol

Synonyms:

Chemical Property of Taltobulin (trifluoroacetate)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Taltobulintrifluoroacetate 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Taltobulin (trifluoroacetate)

There total 21 articles about Taltobulin (trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoroacetic acid (76-05-1) + N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide (228266-39-5) → (S)-N,β,β-trimethylphenylalanyl-(S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoic acid trifluoroacetic acid salt (228266-41-9)

Guidance literature:

N-(tert-butoxycarbonyl)-N,β,β-trimethyl-L-phenylalanine-N-[(3S,4E)-6-ethoxy-2,5-dimethyl-6-oxohexa-4-ene-3-yl]-N,3-dimethyl-L-valinamide; With water; lithium hydroxide; In methanol; at 20 ℃; for 20h;

With citric acid; In methanol; water;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

C31H46F3N3O5 → (S)-N,β,β-trimethylphenylalanyl-(S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoic acid trifluoroacetic acid salt (228266-41-9)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 60 ℃; for 192h; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.202010090

Reference yield:

C31H46F3N3O5 → (R)-N,β,β-trimethylphenylalanyl-(S)-tert-leucyl-(2E,4S)-N-methyl-4-amino-2,5-dimethylhex-2-enoic acid trifluoroacetic acid salt (228266-41-9)

Guidance literature:

With lithium hydroxide monohydrate; In methanol; water; at 60 ℃; for 192h; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.202010090

upstream raw materials:

trifluoroacetic acid

(6S,9S,12S,E)-9-tert-butyl-12-isopropyl-2,2,5,11,14-pentamethyl-4,7,10-trioxo-6-(2-phenylpropan-2-yl)-3-oxa-5,8,11-triazapentadec-13-en-15-oic acid

N-tert-butyloxycarbonyl-L-tert-leucine

ethyl (S,E)-4-((S)-2-((tert-butoxycarbonyl)amino)-N,3,3-trimethylbutanamido)-2,5-dimethylhex-2-enoate

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