Technology Process of stereocalpin A
There total 10 articles about stereocalpin A which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C31H42N2O6;
With
hydrogenchloride;
In
methanol; water;
at 0 - 40 ℃;
With
Dess-Martin periodane;
In
dichloromethane;
at 20 - 40 ℃;
DOI:10.1021/acs.joc.8b00118
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 23 ℃;
for 24h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol900412u
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: palladium 10% on activated carbon / ethanol / 3 h / 20 °C
2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / Inert atmosphere
2.2: 0.5 h / 0 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 20 - 40 °C / Inert atmosphere
4.1: pyridine; pyridine hydrofluoride / tetrahydrofuran / 2 h / 0 - 20 °C
4.2: 2 h / 0 °C
4.3: 1 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 0 - 20 °C
6.1: lithium hydroxide monohydrate; dihydrogen peroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C
7.1: palladium 10% on activated carbon / methanol / 1.5 h / 20 °C
7.2: 2 h / 20 °C
8.1: hydrogenchloride / water; methanol / 0 - 40 °C
8.2: 20 - 40 °C
With
pyridine; hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; pyridine hydrofluoride; palladium 10% on activated carbon; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/acs.joc.8b00118
