5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1224944-68-6
Molecular Formula:C₁₈H₁₅ClN₆O
Molecular Weight:366.81
Hs Code.:

Synonyms:5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of 5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of 5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 6 articles about 5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224944-47-1
5-chloropyrazolo[1,5-a]pyrimidine-3-carbonyl chloride

: 1224944-66-4
3-(2,5-dimethylphenyl)-1H-pyrazol-4-amine

: 1224944-68-6
5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;

Reference yield:

: 1224944-44-8
3-iodopyrazolo[1,5-a]pyrimidin-5(4H)-one

: 1224944-68-6
5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / palladium diacetate / 5 h / 55 °C / Inert atmosphere

2.1: water; lithium hydroxide / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux; Inert atmosphere

4.1: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

With water; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; palladium diacetate; In dichloromethane;

Reference yield:

: 1224944-43-7
sodium pyrazolo[1,5-a] pyrimidin-5-olate

: 1224944-68-6
5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / water / 0.25 h / Inert atmosphere

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / Heating; Inert atmosphere

3.1: triethylamine / palladium diacetate / 5 h / 55 °C / Inert atmosphere

4.1: water; lithium hydroxide / 3 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux; Inert atmosphere

6.1: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

With N-iodo-succinimide; water; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; palladium diacetate; In dichloromethane; water; N,N-dimethyl-formamide;