5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1224944-67-5
Molecular Formula:C₁₉H₁₇ClN₆O
Molecular Weight:380.837
Hs Code.:

Synonyms:5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of 5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of 5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 8 articles about 5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1224944-47-1
5-chloropyrazolo[1,5-a]pyrimidine-3-carbonyl chloride

: 1224944-66-4
3-(2,5-dimethylphenyl)-1H-pyrazol-4-amine

: 1224944-67-5
5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1021/jm3012239

Reference yield:

: 1224944-68-6
5-chloro-N-(3-(2,5-dimethylphenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

: 74-88-4
methyl iodide

: 1224944-67-5
5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 5h; Inert atmosphere;

Reference yield:

: 29274-22-4
4H,5H-pyrazolo[1,5-a]pyrimidine-5-one

: 1224944-67-5
5-chloro-N-(3-(2,5-dimethylphenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / Heating; Inert atmosphere

2.1: triethylamine / palladium diacetate / 5 h / 55 °C / Inert atmosphere

3.1: water; lithium hydroxide / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / Reflux; Inert atmosphere

5.1: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

6.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C / Inert atmosphere

With N-iodo-succinimide; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; trichlorophosphate; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide;