methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

Base Information

Chemical Name:methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate
CAS No.:959938-92-2
Molecular Formula:C₁₇H₂₂N₄O₆
Molecular Weight:378.385
Hs Code.:

Synonyms:methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

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Chemical Property of methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

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Technology Process of methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

There total 8 articles about methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 959938-91-1
trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

: 959938-92-2
methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

Guidance literature:: With hydrazine; In ethanol; at 20 ℃; for 2h;

Reference yield:

: 701232-67-9
trans-[4-(4-hydroxyphenyl)cyclohexyl]acetic methyl ester

: 959938-92-2
methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

3.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

3.2: pH 9

4.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

5.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 19.32 h / 0 - 20 °C

6.1: hydrazine / ethanol / 2 h / 20 °C

With pyridine; ammonium nitrate; hydrogenchloride; methanol; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; hydrazine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 701232-66-8
[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester

: 959938-92-2
methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}-3-nitrophenyl)cyclohexyl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 °C / 1500.15 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

4.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

4.2: pH 9

5.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

6.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 19.32 h / 0 - 20 °C

7.1: hydrazine / ethanol / 2 h / 20 °C

With pyridine; ammonium nitrate; hydrogenchloride; methanol; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; hydrazine; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane;