trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

Base Information

Chemical Name:trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate
CAS No.:959938-91-1
Molecular Formula:C₁₈H₂₂N₂O₇
Molecular Weight:378.382
Hs Code.:

Synonyms:trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

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Chemical Property of trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

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Technology Process of trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

There total 7 articles about trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 892491-69-9
methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate

: 959938-91-1
trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

Guidance literature:: With ammonium nitrate; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 19.32h;

Reference yield:

: 701232-67-9
trans-[4-(4-hydroxyphenyl)cyclohexyl]acetic methyl ester

: 959938-91-1
trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

3.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

3.2: pH 9

4.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

5.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 19.32 h / 0 - 20 °C

With pyridine; ammonium nitrate; hydrogenchloride; methanol; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane;

Reference yield:

: 701232-66-8
[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester

: 959938-91-1
trans-methyl 2-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]-acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 30 °C / 1500.15 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 17.25 h / 4 - 15 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 16 h / Heating / reflux

4.1: hydrogenchloride; methanol; water / 16 h / 4 - 20 °C

4.2: pH 9

5.1: pyridine / dichloromethane / 64 h / 0 - 20 °C

6.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 19.32 h / 0 - 20 °C

With pyridine; ammonium nitrate; hydrogenchloride; methanol; water; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane;