(2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide

Base Information

• Chemical Name: (2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide
• CAS No.: 1011533-95-1
• Molecular Formula: C₃₇H₄₆N₃O₆P
• Molecular Weight: 659.762
• Mol file: 1011533-95-1.mol

Synonyms:(2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide

Chemical Property of (2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide

There total 1 articles about (2R)-O²-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R)-O4-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide (1011533-91-7) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → (2R)-O2-(2-cyanoethoxy-N,N-diisopropylaminophosphinyl)-O4-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide (1011533-95-1)

Guidance literature:

With N,N-diisopropylamine tetrazolide; at 20 ℃; for 12h;

DOI:10.1080/15257770701490936

upstream raw materials:

(2R)-O⁴-(4,4'-dimethoxytrityl)-N-propargyl-2,4-dihydroxybutyramide

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite