{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:783362-48-1
Molecular Formula:C₄₀H₄₄N₄O₈
Molecular Weight:708.811
Hs Code.:

{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9<i>H</i>-fluoren-9-ylmethyl ester

Synonyms:{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of {2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of {2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 10 articles about {2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 783362-48-1
{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / SOCl₂ / 24 h / 20 °C

2: 85 percent / NBS / CCl₄ / 5 h / Irradiation

3: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

4: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

5: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

6: 80 percent / HATU; collidine / dimethylformamide / 12 h

7: piperidine; TFA / dimethylformamide / 0.5 h

8: DIEA / CH₂Cl₂ / 1 h

9: aq. LiOH / methanol / 2 h / 20 °C

10: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; thionyl chloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 2945-08-6
methyl (4-nitrophenyl)acetate

: 783362-48-1
{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / NBS / CCl₄ / 5 h / Irradiation

2: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

3: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

4: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

5: 80 percent / HATU; collidine / dimethylformamide / 12 h

6: piperidine; TFA / dimethylformamide / 0.5 h

7: DIEA / CH₂Cl₂ / 1 h

8: aq. LiOH / methanol / 2 h / 20 °C

9: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 29704-42-5
4-nitromandelic acid methyl ester acetate

: 783362-48-1
{2-[2-(2-{2-[4-(2-acetylamino-3-phenyl-propionylamino)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

2: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

3: 80 percent / HATU; collidine / dimethylformamide / 12 h

4: piperidine; TFA / dimethylformamide / 0.5 h

5: DIEA / CH₂Cl₂ / 1 h

6: aq. LiOH / methanol / 2 h / 20 °C

7: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; tetrafluoroboric acid; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b404471a