1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

Base Information

Chemical Name:1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone
CAS No.:1201632-20-3
Molecular Formula:C₂₄H₂₄ClF₄N₅O
Molecular Weight:509.934
Hs Code.:

Synonyms:1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

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Chemical Property of 1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

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Technology Process of 1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

There total 3 articles about 1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201225-04-8
2-chloro-1-[4-(3-trifluoromethyl-4-chlorophenyl)-1-(3,6-dihydro-1[2H]pyridinyl)]-1-ethanone

: 8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]octane hydrochloride

: 1201632-20-3
1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield:

: 67571-90-8
3-benzyl-3,8-diazabicyclo[3.2.1]octane

: 1201632-20-3
1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / 1-methyl-pyrrolidin-2-one / 5 h / 110 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3.17 h / 0 - 85 °C / Inert atmosphere

2.2: 0.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C

With carbonochloridic acid 1-chloro-ethyl ester; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1-methyl-pyrrolidin-2-one; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1201633-30-8
C₁₇H₁₉FN₄

: 1201632-20-3
1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3.17 h / 0 - 85 °C / Inert atmosphere

1.2: 0.5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C

With carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;