2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

Base Information

• Chemical Name: 2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone
• CAS No.: 1201225-04-8
• Molecular Formula: C14H12Cl2F3NO
• Molecular Weight: 338.15
• Hs Code.: 2933399090
• Mol file: 1201225-04-8.mol

Synonyms:2-chloro-1-(4-(4-chloro-3-(trifluoroMethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone;Ethanone, 2-chloro-1-[4-[4-chloro-3-(trifluoromethyl)phenyl]-3,6-dihydro-1(2H)-pyridinyl]-

Chemical Property of 2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

Chemical Property:

• PSA: 20.31000
• LogP: 4.15120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone

There total 2 articles about 2-Chloro-1-(4-(4-chloro-3-(trifluoromethyl)phenyl)-5,6-dihydropyridin-1(2H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-(trifluoromethyl)-4-chlorophenyl]-3,6-dihydro-1(2H)-pyridine hydrochloride (1201225-05-9) + chloroacetyl chloride (79-04-9) → 2-chloro-1-[4-(3-trifluoromethyl-4-chlorophenyl)-1-(3,6-dihydro-1[2H]pyridinyl)]-1-ethanone (1201225-04-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

→ 2-chloro-1-[4-(3-trifluoromethyl-4-chlorophenyl)-1-(3,6-dihydro-1[2H]pyridinyl)]-1-ethanone (1201225-04-8)

Guidance literature:

Reference yield:

2-chloro-1-[4-(3-trifluoromethyl-4-chlorophenyl)-1-(3,6-dihydro-1[2H]pyridinyl)]-1-ethanone (1201225-04-8) + 8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]octane hydrochloride → 1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone (1201632-20-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

upstream raw materials:

4-[3-(trifluoromethyl)-4-chlorophenyl]-3,6-dihydro-1(2H)-pyridine hydrochloride

chloroacetyl chloride

Downstream raw materials:

1-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-[8-(5-fluoropyrimidin-2-yl)-3,8-diazabicyclo[3.2.1]oct-3-yl]ethanone

4-{2-[4-(4-chloro-3-trifluoromethylphenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl}-1-(5-trifluoromethylpyridin-2-yl)piperazin-2-one

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