(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

Base Information

Chemical Name:(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid
CAS No.:1351279-06-5
Molecular Formula:C₃₈H₅₄O₄
Molecular Weight:574.844
Hs Code.:

(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

Synonyms:(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

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Chemical Property of (1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

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Technology Process of (1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

There total 6 articles about (1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Betulinic acid: 472-15-1
Betulinic acid

: 1351279-06-5
(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen; methanol / palladium 10% on activated carbon / ethyl acetate; methanol / 18 h / 20 °C / 2327.23 Torr

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3.1: pyridinium chlorochromate / dichloromethane / 4 h

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

4.2: 2.33 h / -78 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

6.1: triethylamine / palladium diacetate / dichloromethane / 3 h / 60 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride / 1,4-dioxane / 2 h / 20 °C

With methanol; tetrabutyl ammonium fluoride; hydrogen; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 38736-78-6,25488-53-3
dihydrobetulinic acid

: 1351279-06-5
(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2.1: pyridinium chlorochromate / dichloromethane / 4 h

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

3.2: 2.33 h / -78 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

5.1: triethylamine / palladium diacetate / dichloromethane / 3 h / 60 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / 1,4-dioxane / 2 h / 20 °C

With tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium carbonate; potassium carbonate; triethylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1351279-04-3
(1S,3aS,5aR,5bR,7aR,11aR,13aR, 13bR)-benzyl 1-isopropyl-5a,5b,8,8,11a-pentamethyl-9-(trifluoromethylsulfonyloxy)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate

: 1351279-06-5
(1S,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-1-isopropyl-9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxyic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

2: triethylamine / palladium diacetate / dichloromethane / 3 h / 60 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / 1,4-dioxane / 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; dichloromethane; water;