Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Base Information

Chemical Name:Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph
CAS No.:144073-32-5
Molecular Formula:C₅₆H₆₈N₆O₉
Molecular Weight:969.191
Hs Code.:

Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH<sub>2</sub>Ph

Synonyms:Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Suppliers and Price of Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Chemical Property:

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Technology Process of Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

There total 19 articles about Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2448-45-5
Cbz-D-Phe

: L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

: 144073-32-5
Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; Ambient temperature;
DOI:10.1021/jm00099a019

Reference yield:

: 1027545-12-5
L-Pip-D-Phe-L-Pro-OCH₂Ph

: 144073-32-5
Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

2: diethylamine / acetonitrile / Ambient temperature

3: 78 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

4: diethylamine / acetonitrile / Ambient temperature

5: 90 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent), N,N-diisopropylethylamine (DIEA) / acetonitrile / Ambient temperature

With silver cyanide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00099a019

Reference yield:

: 1026676-51-6
D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

: 144073-32-5
Cbz-D-Phe-L-Ile-D-Pip-L-Pip-D-Phe-L-Pro-OCH₂Ph

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

2: diethylamine / acetonitrile / Ambient temperature

3: 90 percent / benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent), N,N-diisopropylethylamine (DIEA) / acetonitrile / Ambient temperature

With silver cyanide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;
DOI:10.1021/jm00099a019