2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester

Base Information

• Chemical Name: 2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester
• CAS No.: 1157580-17-0
• Molecular Formula: C₃₁H₃₇NO₄
• Molecular Weight: 487.639

Synonyms:2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester

Chemical Property of 2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester

Chemical Property:

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Technology Process of 2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester

There total 1 articles about 2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(4-iodo-phenyl)-cyclohexyl]-(1-naphthalen-1-yl-ethyl)-amine (1157580-06-7) + diethyl malonate (105-53-3) → 2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester (1157580-17-0)

Guidance literature:

With caesium carbonate; copper(l) iodide; 2-Phenylphenol; In tetrahydrofuran; at 100 ℃; for 192h;

Reference yield:

2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-malonic acid diethyl ester (1157580-17-0) → {4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-acetic acid ethyl ester (1157580-18-1)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 150 ℃;

upstream raw materials:

[3-(4-iodo-phenyl)-cyclohexyl]-(1-naphthalen-1-yl-ethyl)-amine

diethyl malonate

Downstream raw materials:

{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-acetic acid ethyl ester

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