tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate
CAS No.:524712-14-9
Molecular Formula:C₂₃H₂₄BrNO₄
Molecular Weight:458.352
Hs Code.:

Synonyms:tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Suppliers and Price of tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

There total 10 articles about tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 524712-13-8
2-(2-bromophenyl)-2-(3-oxobutyl)-1,2-dihydro-3H-indol-3-one

: 524712-14-9
tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 17h;
DOI:10.1021/ja021380m

Reference yield:

: 88207-45-8
2-(2'-bromophenyl)-1H-indole

: 524712-14-9
tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / NaNO₂ / acetic acid / 3 h / 20 °C

2: 94 percent / Na₂S₂O₄; NaOH / ethanol / 24 h / Heating

3: 98 percent / PbO₂ / benzene / 24 h / Heating

4: 56 percent / aq. HCl / toluene / 12 h / 20 °C

5: 88 percent / tetrahydrofuran / 1 h / 20 °C

6: 89 percent / HCOOH / toluene / 0.5 h / Heating

7: 96 percent / 4-(dimethylamino)pyridine / acetonitrile / 17 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; formic acid; sodium dithionite; lead dioxide; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid; toluene; acetonitrile; benzene;
DOI:10.1021/ja021380m

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 524712-14-9
tert-butyl 2-(2-bromophenyl)-3-oxo-2-(3-oxobutyl)indoline-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / polyphosphoric acid / 4 h / 100 - 110 °C

2: 97 percent / NaNO₂ / acetic acid / 3 h / 20 °C

3: 94 percent / Na₂S₂O₄; NaOH / ethanol / 24 h / Heating

4: 98 percent / PbO₂ / benzene / 24 h / Heating

5: 56 percent / aq. HCl / toluene / 12 h / 20 °C

6: 88 percent / tetrahydrofuran / 1 h / 20 °C

7: 89 percent / HCOOH / toluene / 0.5 h / Heating

8: 96 percent / 4-(dimethylamino)pyridine / acetonitrile / 17 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; formic acid; sodium dithionite; PPA; lead dioxide; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid; toluene; acetonitrile; benzene; 1: Fischer indole synthesis;
DOI:10.1021/ja021380m